Dose Escalation for Oligometastatic Disease: Is More Better?

Most of the randomized evidence for the optimal radiotherapeutic treatment of metastases was conducted in polymetastatic disease with the goal of symptom management. In particular, for painful bone metastasis, numerous trials have compared various lower dose radiation therapy schedules (eg, 8 Gy × 1, 4 Gy × 5, 3 Gy × 10), with no differences in pain response.1-3 Although the primary goal was met, many showed pain control durability of only 12 weeks and high rates of local failure in the few trials that tracked this outcome.
Source: International Journal of Radiation Oncology * Biology * Physics - Category: Radiology Authors: Tags: Editorial Source Type: research