Hybrid stomach-intestinal chromatin states underlie human Barrett ’s metaplasia

Tissue metaplasia is uncommon in adults because established cis-element programs resist rewiring. In Barrett ’s esophagus, the distal esophageal mucosa acquires predominantly intestinal character, with notable gastric features, and is predisposed to develop invasive cancers. We sought to understand the chromatin underpinnings of Barrett’s metaplasia and why it commonly displays simultaneous gastric and intestinal properties.

Source: Gastroenterology - June 2, 2021 Category: Gastroenterology Authors: Harshabad Singh, Kyungsik Ha, Jason L. Hornick, Shariq Madha, Paloma Cejas, Kunal Jajoo, Pratik Singh, Paz Polak, Hwajin Lee, Ramesh A. Shivdasani Source Type: research