Comparative pharmacokinetic analysis of raw and steamed < em > Panax notoginseng < /em > roots in rats by UPLC-MS/MS for simultaneously quantifying seven saponins

CONCLUSIONS: Influence of the processing reduced the systemic exposure levels to GRg1, GRb1, GRd and NGR1. It is the first report of comparative pharmacokinetic study of multiple saponins analysis after oral administration of RPN and SPN extract, which might be helpful for further studies on its steam-processing mechanism.PMID:34062093 | DOI:10.1080/13880209.2021.1928239

Source: Pharmaceutical Biology - June 1, 2021 Category: Drugs & Pharmacology Authors: Jiajia Dong Zhenzhen Yin Lianlin Su Mengting Yu Meng Wang Lin Li Chunqin Mao Tulin Lu Source Type: research