New alkaloids from the noni juice with potential α-glucosidase inhibitory activity

Fitoterapia. 2021 May 25:104946. doi: 10.1016/j.fitote.2021.104946. Online ahead of print.ABSTRACTFour new alkaloids, nonialkaloids A-D (1-4) and six known analogues (5-10) were isolated from the noni juice. Among the new compounds, 1 and 2 are indole alkaloids with a seven-membered fused N-heterocyclic ring, 3 and 4 are quaternary ammonium derivatives. The structures were elucidated by extensive NMR and MS analysis, while the absolute configurations of the stereogenic carbons were established based on quantum-chemical electronic circular dichroism calculations or the modified Mosher's method. All the isolates were tested for α-glucosidase inhibitory activities. Compounds 1 and 3 displayed potent inhibitory activity against α-glucosidase with the IC50 values of 413.7 and 364.4 μM, respectively.PMID:34048830 | DOI:10.1016/j.fitote.2021.104946
Source: Fitoterapia - Category: Biochemistry Authors: Source Type: research