CNS-3 status remains an independent adverse prognosis factor in children with acute lymphoblastic leukemia (ALL) treated without cranial irradiation: Results of EORTC Children Leukemia Group study 58951

CONCLUSIONS: CNS-3 status remains associated with poor prognosis and requires intensification of both systemic and CNS-directed therapy. This trial was registered at https://clinicaltrials.gov/under/NCT00003728.PMID:34034929 | DOI:10.1016/j.arcped.2021.04.009

Source: Archives de Pediatrie - May 26, 2021 Category: Pediatrics Authors: N Sirvent S Suciu B De Moerloose A Ferster F Mazingue G Plat K Yakouben A Uyttebroeck C Paillard V Costa P Simon C Pluchart M Poir ée O Minckes F Millot C Freycon P Maes C Hoyoux H Cav é P Rohrlich Y Bertrand Y Benoit Children's Leukemia Group of the Eu Source Type: research