Carcinoma Cuniculatum of the Oral Cavity: A Series of 6 Cases and Review of Literature

AbstractCarcinoma cuniculatum (CC) is a rare variant of squamous cell carcinoma (SCC) that is characterized by minimal cytologic atypia and a unique deeply infiltrative growth pattern resembling rabbit burrows (cuniculi). With less than 75 cases reported in the head and neck, the clinical and pathologic spectrum of this entity remains poorly understood. A retrospective review of the clinical and pathologic features of archival cases of oral CC was performed. A total of six cases of oral CC were identified. Age ranged from 25-77 years; the male-to-female ratio was 5:1. All patients had a long-standing history of tobacco and betel-quid consumption. The tumors were distributed in the gingivobuccal sulcus (n  = 2), the tongue (n = 2), buccal mucosa (n = 1), and the palate (n = 1). Histology in all cases typically revealed a tumor composed of well-differentiated squamous epithelium, devoid of atypia, lining deeply infiltrative, large-sized, branching, keratin-filled cavities, resembling r abbit-burrows. Dense lymphocytic infiltrates and discharging micro-abscesses were regular features. Underlying bone invasion and lymph node metastasis were observed in 1 patient. One patient with a tongue tumor developed locoregional recurrence at 10 months while none developed distant metastasis. Oral CC is a rare and under-recognized variant of SCC with locally aggressive behavior. Lack of familiarity with this variant exacerbated by ...
Source: Head and Neck Pathology - Category: Pathology Source Type: research

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We describe the main characteristics of this entity and we report a case of oral carcinoma cuniculatum of the buccal left mucosa treated with resection and sentinel lymph node biopsy.
Source: Revista Espanola de Cirugia Oral y Maxilofacial - Category: ENT & OMF Source Type: research
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Source: Cancers - Category: Cancer & Oncology Authors: Tags: Systematic Review Source Type: research
Elampavai Elangovan, Abhishek Banerjee, Abhinandan, Bireswar RoyJournal of Oral and Maxillofacial Pathology 2021 25(1):163-166 Oral Carcinoma cuniculatum(OCC) is rare variant of squamous cell carcinoma. The histopathological features of this type of carcinoma makes it special in the literature of Pathology. The appearance of deep invading epithelial islands with pool of keratin cores very similar to rabbit burrows gives the term cuniculatum to the carcinoma. Here we present a case of OCC on the lateral surface of the tongue. Early diagnosis of such case is very important to distinguish it distinctly from the other entitie...
Source: Journal of Oral and Maxillofacial Pathology - Category: ENT & OMF Authors: Source Type: research
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Source: Journal of Oncology - Category: Cancer & Oncology Authors: Source Type: research
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Source: Primary dental care : journal of the Faculty of General Dental Practitioners UK - Category: Dentistry Authors: Source Type: research
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