Hypoactive thalamic Crh+ cells in a female mouse model of alcohol drinking after social trauma

Comorbid stress-induced mood and alcohol use disorders are increasingly prevalent among female patients. Stress exposure can disrupt salience processing and goal-directed decision making, contributing to persistent maladaptive behavioral patterns; these and other stress-sensitive cognitive and behavioral processes rely on dynamic and coordinated signaling by midline and intralaminar thalamic nuclei. Considering the role of social trauma in the trajectory of these debilitating psychopathologies, identifying vulnerable thalamic cells may provide guidance for targeting persistent stress-induced symptoms.

Source: Biological Psychiatry - May 31, 2021 Category: Psychiatry Authors: Emily L. Newman, Herbert E. Covington, Michael Z. Leonard, Kelly Burk, Klaus A. Miczek Tags: Archival Report Source Type: research