Mechanisms of Stress-Induced Sleep Disturbance Give New Insight Into Stress Vulnerability

Current treatments for depression fail to adequately treat the disorder in many people. Even among those for whom treatment is effective, depression will often return, with each episode further increasing the risk for a subsequent episode, making prevention an important goal in developing new treatments. Stress can trigger depression, but there is considerable variability in how individuals respond, with some developing the disorder and others developing resilience. Recent work has identified brain region –specific metabolic profiles (1), neural activity (2), and preexisting behavioral alterations that associate with susceptibility to future stress in rodents.
Source: Biological Psychiatry - Category: Psychiatry Authors: Tags: Commentary Source Type: research