Love it or Leave it: Differential Modulation of Incentive Motivation by Corticotropin-Releasing Factor Neurons

Corticotropin-releasing factor (CRF) is a neuropeptide critical to behavioral and physiological responses to stressors. CRF was originally discovered as an initiator of the hypothalamic-pituitary-adrenal axis, where it is released from neurons of the paraventricular nucleus of the hypothalamus into the pituitary gland. CRF was subsequently detected in the central amygdala (CeA) and bed nucleus of the stria terminalis (BNST) and was found to mediate negative valence associated with stress, anxiety, and drug withdrawal.
Source: Biological Psychiatry - Category: Psychiatry Authors: Tags: Commentary Source Type: research