Benefits of flavonoid and metronidazole use after excisional hemorrhoidectomy: a randomized double-blind clinical trial

AbstractBackgroundExcisional hemorrhoidectomy remains the most effective treatment for a significant group of patients with hemorrhoids, despite the potential for postoperative pain. The purpose of this study was to evaluate the effects of flavonoid and metronidazole use in the postoperative period on patients undergoing excisional hemorrhoidectomy.MethodsA double-blind randomized clinical study was performed. Sixty-eight patients underwent excisional hemorrhoidectomy and were randomized into 4 groups of 17 patients each to receive double-placebo (G1), metronidazole plus placebo (G2), flavonoids plus placebo (G3) or metronidazole plus flavonoids (G4) in the postoperative period. A standard analgesic protocol was offered equally for all groups. Postoperative pain, bleeding, edema, pruritus and tenesmus were evaluated during the following three periods: from immediately after the operation until postoperative day (POD)7, from POD 8 to POD 14, and from POD 15 to POD 30. The patients were required to complete symptom questionnaires and to attend postoperative follow-up on PODs 7, 14 and 30. The effect of each drug was assessed for each symptom, and the groups were compared with each other and over time.ResultsThere was less severe pain in all postoperative periods in the groups using flavonoids (G3 and G4, bothp 
Source: Techniques in Coloproctology - Category: Surgery Source Type: research

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Asian J Surg. 2021 Nov 25:S1015-9584(21)00730-2. doi: 10.1016/j.asjsur.2021.11.032. Online ahead of print.ABSTRACTBACKGROUND: This prospective randomized controlled study compared the short- and long-term efficacy and advantages of modified Park's submucosal over Milligan-Morgan hemorrhoidectomy (MMH) in the treatment of grade III and IV circumferential prolapsed hemorrhoids (CPH).METHODS: A total of 186 consecutive patients with grade III or IV CPH were enrolled. The patients were randomized to MPSH (n = 93) or MMH (n = 93) treatment groups. Patient data included demographics, clinical characteristics, surgical parameters...
Source: Asian Journal of Surgery - Category: Surgery Authors: Source Type: research
Clin Ter. 2021 Nov 22;172(6):520-522. doi: 10.7417/CT.2021.2369.ABSTRACTHaemorrhoids are considered among the most frequent proctologi-cal condition at a general practitioner (GP) practice. Acute prolapse of internal haemorrhoids is presented with oedema, inflammation and acute pain. The application of granulated sugar on swollen hae-morrhoids leads to an immediate reduction of their edema and to the patient's relief. After the topical application of sugar, haemorrhoids begin to shrink immediately and edema is drastically reduced, while haemorrhoidal tissue can easily retracted back into the anal canal. The method is a che...
Source: Clinical Colorectal Cancer - Category: Cancer & Oncology Authors: Source Type: research
In this study, we plan to include 186 patients who have undergone modified Milligan-Morgan hemorrhoidectomy, which only sutured external hemorrhoids to reduce the risk of bleeding. The purpose is to determine whether the use of nonpressure dressings after open hemorrhoidectomy is inferior to the use of pressure dressings in terms of severe postoperative bleeding and postoperative complications. The primary endpoints of the trial are the incidence of urinary retention within 24  h after surgery and the incidence of severe postoperative bleeding 1 h after dressing removal, which requires revision surgery within...
Source: Trials - Category: Research Source Type: clinical trials
CONCLUSION: Rectal suppositories containing a combined extract of CQ and AP show potential in alleviating hemorrhoidal symptoms with a good safety profile.PMID:34765003 | PMC:PMC8577889 | DOI:10.1155/2021/5605323
Source: Evidence-based Complementary and Alternative Medicine - Category: Complementary Medicine Authors: Source Type: research
Conditions:   Hemorrhoid;   Hemorrhoids;   Hemorrhoids Internal;   Hemorrhoid Prolapse;   Hemorrhoid Bleeding;   Hemorrhoid Pain Interventions:   Other: Endoscopic injection sclerotherapy;   Other: Endoscopic Band Ligation Sponsors:   Renmin Hospital of Wuhan University;   Zhejiang University;   The First Affiliated Hospital of Nanchang University;   Army Military Medical University Southwestern Hospital;   Shanxi Provincial Coal Central Hospital;   Hubei ...
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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