Donor-Host Lineage-Specific Chimerism Monitoring and Analysis in Pediatric Patients Following Allogeneic Stem Cell Transplantation: Influence of Pre-Transplantation Variables and Correlation with Post-Transplant Outcomes

Allogeneic hematopoietic stem cell transplant (HSCT) remains one of the curative therapies for malignant and non-malignant hematologic and immune disorders.1 Long-term outcome of HSCT depends on several variables including age, disease, conditioning regimen, type of graft, graft manipulation, and graft-versus-host disease (GvHD) prophylaxis. Given recent advances in laboratory methodology, we can now study donor-host chimerism post-HCST in more detail by analyzing donor-host percentages for different hematopoietic lineages.   Despite increased knowledge on donor-host chimerism status post-HSCT, its impact remains poorly understood.

Source: Biology of Blood and Marrow Transplantation - May 30, 2021 Category: Hematology Authors: Gabriela Llaurador, Eileen Nicoletti, Susan E Prockop, Susan Hsu, Kirsten Fuller, Audrey Mauguen, Gabriela O'Reilly, Jaap J Boelens, Farid Boulad Source Type: research