Can quantitative analysis of multi-parametric MRI independently predict failure of focal salvage HIFU therapy in men with radio-recurrent prostate cancer?

CONCLUSIONS: One pharmacokinetic quantitative parameter based on DCE sequences seems to independently predict failure following focal salvage HIFU for radio-recurrent prostate cancer. This likely relates to the tumor microenvironment producing heat-sinks which counter the heating effect of HIFU. Further validation in larger datasets and evaluating mechanisms to reduce heat-sinks are required.PMID:34049783 | DOI:10.1016/j.urolonc.2021.04.017

Source: Urologic Oncology - May 29, 2021 Category: Urology & Nephrology Authors: Arnas Rakauskas Taimur T Shah Max Peters Jagpal S Randeva Feargus Hosking-Jervis Michael J Schmainda Clement Orczyck Mark Emberton Manit Arya Caroline Moore Hashim U Ahmed Source Type: research