< em > Msx1 < /em > Heterozygosity in Mice Enhances Susceptibility to Phenytoin-Induced Hypoxic Stress Causing Cleft Palate

CONCLUSION: Our data suggest that cleft palate may occur because of the additive effects of Bmp4 downregulation as a result of Msx1 heterozygosity and decreased cell proliferation upon hypoxic stress. Human carriers of MSX1 mutations may have to take more precautions during pregnancy to avoid exposure to environmental risks.PMID:34047208 | DOI:10.1177/1055665620962690

Source: The Cleft Palate-Craniofacial Journal - May 28, 2021 Category: ENT & OMF Authors: Jinsil Park Mitsushiro Nakatomi Masaaki Sasaguri Manabu Habu Osamu Takahashi Daigo Yoshiga Kae Matsuyama Shinji Kataoka Takashi Toyono Yuji Seta Heiko Peters Kazuhiro Tominaga Source Type: research