Predicting protein complexes from weighted protein-protein interaction graphs with a novel unsupervised methodology: evolutionary enhanced Markov clustering

Conclusions EE-MC is by design able to overcome intrinsic limitations of existing methodologies such as their inability to handle weighted PPI networks, their constraint to assign every protein in exactly one cluster and the difficulties they face concerning the parameter tuning. This fact was experimentally validated and moreover, new potentially true human protein complexes were suggestedas candidates for further validation using experimental techniques.
Source: Artificial Intelligence in Medicine - Category: Bioinformatics Source Type: research