Effects of Mechanical Compression on Cell Morphology and Function in Human Corneal Fibroblasts

Conclusions: Mechanical compression alters cell morphology, inhibits proliferation, induces apoptosis, upregulates genes related to extracellular matrix degradation, and downregulates corneal structural genes in human corneal fibroblasts. This study provides evidence that compressive stress significantly influences corneal keratocytes. Our findings suggest that this mechanical effect may be related to keratoconus associated with chronic eye rubbing.PMID:34039223 | DOI:10.1080/02713683.2021.1904510
Source: Current Eye Research - Category: Opthalmology Authors: Source Type: research