Bone Growth Capacity of Human Umbilical Cord Mesenchymal Stem Cells and BMP-2 Seeded Into Hydroxyapatite/Chitosan/Gelatin Scaffold in Alveolar Cleft Defects: An Experimental Study in Goat

CONCLUSION: The HA/Cs/Gel+BMP-2+hUCMSCs were superior in enhancing new bone growth without donor site morbidity compared to ICABG. The presence of hUCMSCs in tissue-engineered alveolar bone graft (ABG), supported with paracrine activity of the resident stem cells, initiated earlier new bone repopulation, and completed faster bone regeneration. The HA/Cs/Gel scaffold seeded with UCMSCs+BMP-2 is a safe substitute of ICABG to close alveolar bone defects suitable for patients with cleft lip, alveolus, and palate.PMID:34047209 | DOI:10.1177/1055665620962360

Source: The Cleft Palate-Craniofacial Journal - May 28, 2021 Category: ENT & OMF Authors: Kristaninta Bangun Chaula L Sukasah Ismail H Dilogo Decky J Indrani Nurjati Chairani Siregar Jacub Pandelaki Diah Iskandriati Aria Kekalih Jessica Halim Source Type: research