Can we decloak how infections drive complications after lung transplantation?

Infections are a major risk factor for chronic lung allograft dysfunction (CLAD), which is the main attributable long-term cause of mortality in lung transplant (LTx) recipients.1 –3 Gram-negative organisms such as Pseudomonas aeruginosa are particularly notorious. In experimental models of lung transplantation, Pseudomonas was shown to facilitate a G-CSF-mediated neutrophilia, followed by effector T cell responses, thus contributing to acute rejection.4 Additionally, Pseud omonas also contributes to humoral alloimmunity, which is a known risk factor for CLAD.

Source: The Journal of Heart and Lung Transplantation - May 28, 2021 Category: Transplant Surgery Authors: Hrishikesh S. Kulkarni, Erika D. Lease Tags: Editorial Source Type: research