Mediation of Interleukin ‐23 and Tumor Necrosis Factor–Driven Reactive Arthritis by Chlamydia‐Infected Macrophages in SKG Mice

ConclusionC muridarum load is higher in SKG mice than in BALB/c mice. Whereas proinflammatory IL-23 produced by neutrophils contributes to the initiation ofC muridarum–mediated ReA, macrophage depletion reducesC muridarum dissemination to other tissues, tissue burden, and the development of arthritis. TNF inhibition was also shown to suppress arthritis development. Our data suggest that enhanced bacterial dissemination in macrophages of SKG mice drives the TNF production needed for persistent arthritis.

Source: Arthritis and Rheumatology - May 28, 2021 Category: Rheumatology Authors: Xavier Romand, Xiao Liu, M. Arifur Rahman, Zaied Ahmed Bhuyan, Claire Douillard, Reena Arora Kedia, Nathan Stone, Dominique Roest, Zi Huai Chew, Amy J. Cameron, Linda M. Rehaume, Aur élie Bozon, Mohammed Habib, Charles W. Armitage, Minh Vu Tags: Original Article Source Type: research