Sierra Leone: Ebola Survivors - Their Health Struggles and How Best to Support Them

[The Conversation Africa] West Africa's Ebola outbreak between 2013 and 2016 was the most widespread in the history of the disease. By the end of the outbreak, more than 28,000 people were infected and 11,000 succumbed to the disease.
Source: AllAfrica News: Health and Medicine - Category: African Health Source Type: news

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Biomed Res Int. 2021 Sep 8;2021:9989478. doi: 10.1155/2021/9989478. eCollection 2021.ABSTRACTINTRODUCTION: Recent experiences from global outbreaks have highlighted the severe disruptions in sexual and reproductive health services that expose women and girls to preventable health risks. Yet, to date, there is no review studying the possible impact of outbreaks on sexual and reproductive health (SRH). Methodology. Studies reporting outbreaks impacting sexual and reproductive health and pregnancy outcomes were identified using MEDLINE, Embase, and ISI-WoS. Reported impacts were reviewed at systems, community, and legislative...
Source: Biomed Res - Category: Research Authors: Source Type: research
This study identified some of the factors that complicated the outbreak, which include delay in the identification of the pathogen, weak health systems, unavailability of licensed drugs or vaccines for the disease, delay in global responses, and cultural practices. Responses were mostly limited to testing, barrier nursing, and treatment of complications. Experimental drugs and vaccines were deployed on compassionate grounds, few have been further developed, trialed, and licensed. It is therefore expected that the current outbreak of Ebola virus disease in Guinea will be better managed.PMID:34537503 | DOI:10.1016/j.coph.2021.08.002
Source: Current Opinion in Pharmacology - Category: Drugs & Pharmacology Authors: Source Type: research
J Mol Biol. 2021 Sep 16:167249. doi: 10.1016/j.jmb.2021.167249. Online ahead of print.ABSTRACTIn the past decade, emerging virus outbreaks like SARS-CoV-2, Zika and Ebola have presented major challenges to the global health system. Viruses are unique pathogens in that they fully rely on the host cell to complete their lifecycle and potentiate disease. Therefore, programmed cell death (PCD), a key component of the host innate immune response, is an effective strategy for the host cell to curb viral spread. The most well-established PCD pathways, pyroptosis, apoptosis and necroptosis, can be activated in response to viruses....
Source: Mol Biol Cell - Category: Molecular Biology Authors: Source Type: research
Purpose of review Due to the impact of the COVID-19 pandemic this past year, we have witnessed a significant acceleration in the science, technology, and policy of global health security. This review highlights important progress made toward the mitigation of Zika, Ebola, and COVID-19 outbreaks. These epidemics and their shared features suggest a unified policy and technology agenda that could broadly improve global health security. Recent findings Molecular epidemiology is not yet in widespread use, but shows promise toward informing on-the-ground decision-making during outbreaks. Point-of-care (POC) diagnostic...
Source: Current Opinion in Infectious Diseases - Category: Infectious Diseases Tags: TROPICAL AND TRAVEL-ASSOCIATED DISEASES: Edited by Christina M. Coyle Source Type: research
Scientists believe a 2021 outbreak of the disease in Guinea came from dormant virus reactivating in an otherwise healthy survivor from an epidemic that ended five years ago.
Source: Healthcare News - Category: Pharmaceuticals Authors: Tags: Business /business Innovation /innovation Healthcare /healthcare Science /science Breaking breaking-news Editors' Pick editors-pick Source Type: news
Nature, Published online: 15 September 2021; doi:10.1038/s41586-021-03901-9The viral lineage responsible for the February 2021 outbreak of Ebola virus disease in Guinea is nested within a clade that predominantly consists of genomes sampled during the 2013–2016 epidemic, suggesting that the virus might have re-emerged after a long period of latency within a previously infected individual.
Source: Nature AOP - Category: Research Authors: Source Type: research
ConclusionML methods could reduce bias and increase the precision in CFR estimates at low levels of missingness. However, no method is robust to high percentages of missingness. Thus, a datacentric approach is recommended in outbreak settings —patient survival outcome data should be prioritised for collection and random-sample follow-ups should be implemented to ascertain missing outcomes.
Source: PLoS One - Category: Biomedical Science Authors: Source Type: research
Nature, Published online: 15 September 2021; doi:10.1038/d41586-021-02378-wA genomic comparison of Ebola virus from the 2021 outbreak in Guinea with sequences from the West African outbreak that ended in 2016 suggests that the virus can remain latent in human survivors for an extended period of time.
Source: Nature AOP - Category: Research Authors: Source Type: research
NEW BRUNSWICK, N.J., September 13, 2021 – Data from two papers published in The Lancet Infectious Diseases demonstrated that the Johnson &Johnson (the Company) Ebola vaccine regimen, Zabdeno® (Ad26.ZEBOV) and Mvabea® (MVA-BN-Filo), generated robust humoral (antibody) immune responses in adults and children (ages 1-17) with the immune responses persisting in adults for at least two years. The data also showed that booster vaccination with Ad26.ZEBOV, administered to adults two years after the initial vaccination, induced a strong anamnestic (immune) response within seven days. These findings support the po...
Source: Johnson and Johnson - Category: Pharmaceuticals Source Type: news
Acta Med Okayama. 2021 Aug;75(4):487-493. doi: 10.18926/AMO/62401.ABSTRACTEbola virus disease (EVD) is a highly contagious and fatal disease in humans. Healthcare providers (HCPs) are often at the frontline of epidemics and can thus be in jeopardy of contracting EVD. Sudan is at a great risk of an EVD outbreak, as it borders countries that experienced EVD outbreaks. It is therefore imperative in Sudan to assess the HCPs' awareness and knowledge, attitude, and practice (KAP) about EVD for its control and man-agement and for preparedness. A KAP survey was conducted among 387 HCPs (physicians, nurses and labora-tory technicia...
Source: Acta Med Okayama - Category: Universities & Medical Training Authors: Source Type: research
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