Content of circulating tumor DNA depends on the tumor type and the dynamics of tumor size, but is not influenced significantly by physical exercise, time of the day or recent meal

The development of cancer always involves the acquisition of somatic mutations. When a critical mass of tumor volume is achieved, mutated tumor-derived DNA can often be detected in the plasma and other body liquids. The mechanism of tumor DNA shedding into the bloodstream is not entirely understood. It is believed, that dying tumors cells, which are destroyed by apoptosis, necrosis or other types of cell death, are the main source of circulating tumor DNA (ctDNA) [1, 2].

Source: Cancer Genetics and Cytogenetics - May 28, 2021 Category: Genetics & Stem Cells Authors: Ekaterina S. Kuligina, Roman Meerovich, Kirill A. Zagorodnev, Maxim M. Kholmatov, Tatyana N. Sokolova, Tatiana A. Laidus, Aleksandr A. Romanko, Aleksandr S. Martianov, Maria O. Anisimova, Olga A. Zaitseva, Olga S. Yatsuk, Grigoriy A. Yanus, Evgeny N. Imya Source Type: research