Aspiration of Conjugated Bile Acids Predicts Adverse Lung Transplant Outcomes and Correlates with Airway Lipid and Cytokine Dysregulation

: Duodeno-gastroesophageal reflux aspiration is associated with chronic lung allograft dysfunction (CLAD). Reflux aspirate can contain bile acids (BA), functional molecules in the gastro-intestinal tract with emulsifying properties. We sought to determine and quantify the various BA species in airways of the lung transplant recipients to better understand the various effects of aspirated BA that contribute to post-transplantation outcomes.

Source: The Journal of Heart and Lung Transplantation - May 27, 2021 Category: Transplant Surgery Authors: Andreacarola Urso, Miguel M Leiva-Ju árez, Domenica F. Briganti, Beatrice Aramini, Luke Benvenuto, Joseph Costa, Renu Nandakumar, Estela Area Gomez, Hilary Y Robbins, Lori Shah, Aversa Meghan, Joshua R Sonnet, Selim Arcasoy, Serge Cremers, Frank D'Ovidio Source Type: research