UAlberta researchers wind up a 40-year-old debate on betaretrovirus infection in humans

(University of Alberta Faculty of Medicine &Dentistry) Research from the University of Alberta is shedding new light on primary biliary cirrhosis, a rare liver disease that affects up to one in 500 middle-aged women. In a study published in the journal Alimentary Pharmacology and Therapeutics, Andrew Mason, a professor of medicine in the Department of Medical Microbiology and Immunology, proves that patients with the disease are infected with human betaretrovirus -- a virus resembling a mouse mammary tumor virus.
Source: EurekAlert! - Medicine and Health - Category: Global & Universal Source Type: news

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Conclusions: Multiple risk factors for rALDs were identified, such as colectomy before LT, cholangiocacinoma, multiple episodes of acute cellular rejection, model for end-stage liver disease score, and especially the use of mycophenolate mofetil, cyclosporin A and tacrolimus.
Source: Medicine - Category: Internal Medicine Tags: Research Article: Systematic Review and Meta-Analysis Source Type: research
We describe a relatively young cirrhotic woman who developed splenic infarctions in the setting of alcoholic hepatitis. PMID: 32313472 [PubMed]
Source: Baylor University Medical Center Proceedings - Category: Universities & Medical Training Authors: Tags: Proc (Bayl Univ Med Cent) Source Type: research
We describe the case of a 50-year-old female patient with class II obesity and primary biliary cirrhosis, evaluated for mixed dyslipidemia with poor control (statins and fibrates were being administered) as well as abnormal liver tests. The investigation carried out revealed primary auto-immune hypothyroidism. After normalisation of thyroid function by treatment with levothyroxine, as well as suspending the administration of statins and fibrates, there was an improvement in the lipid profile, although hypercholesterolemia continued. During this time, the patient was diagnosed with diabetes and she re-commenced statin thera...
Source: Acta Medica Portuguesa - Category: General Medicine Tags: Acta Med Port Source Type: research
ConclusionsThere are differences in ANA positivity among patients with SARD and various liver diseases. Some mixed patterns may provide important evidence for the diagnosis of PBC. Clinicians should pay attention to ANA patterns and titer during the interpretation of this test.Key Points• Defining the clinical relevance of antinuclear antibody (ANA) using indirect immunofluorescence assay in the context of diseases can be an important tool for the clinician in the diagnostic work-up of patients with liver diseases.• The mixed pattern of ANA is majorly found in primary biliary cirrhosis (PBC). ANA patterns includi...
Source: Clinical Rheumatology - Category: Rheumatology Source Type: research
AbstractFamilial lecithin:cholesterol acyltransferase (LCAT) deficiency (FLD) is a rare genetic disease characterized by low HDL ‐C levels, low plasma cholesterol esterification, and the formation of Lipoprotein‐X (Lp‐X), an abnormal cholesterol‐rich lipoprotein particle. LCAT deficiency causes corneal opacities, normochromic normocytic anemia, and progressive renal disease due to Lp‐X deposition in the glomeruli. R ecombinant LCAT is being investigated as a potential therapy for this disorder. Several hepatic disorders, namely primary biliary cirrhosis, primary sclerosing cholangitis, cholestatic liver disease, ...
Source: Pharmacology Research and Perspectives - Category: Drugs & Pharmacology Authors: Tags: ORIGINAL ARTICLE Source Type: research
Conclusions: Liver biopsy - despite the increasing access to new, non-invasive methods - remains a useful method in the differential diagnosis of liver diseases. PMID: 31749874 [PubMed]
Source: Archives of Medical Science - Category: General Medicine Tags: Arch Med Sci Source Type: research
Abstract The major histocompatibility complex class II (MHC II) - CD4 immunologic synapse is classically described between the T cell receptor of CD4 positive lymphocytes and MHC II on antigen presenting cells. This interaction and others between surrounding costimulatory and checkpoint molecules promotes differentiation of naïve CD4 T lymphocytes into helper T cells subtypes including Th1, Th2, and Th17 that have more tailored immunologic responses. Although MHC II is mainly produced by professional antigen presenting cells, it can be aberrantly produced by other cell types, including hepatocytes in various ...
Source: Am J Pathol - Category: Pathology Authors: Tags: Am J Pathol Source Type: research
Hepatic pseudolymphoma is a very rare benign reactive lymphoid hyperplasia associated with autoimmunity and chronic inflammatory liver diseases such as primary biliary cirrhosis and may mimic hepatocellular carcinoma. This diagnosis should be suspected in female with a suspicious single tumor. Close monitoring is needed in view of its premalignant nature. AbstractHepatic pseudolymphoma is a very rare benign reactive lymphoid hyperplasia associated with autoimmunity and chronic inflammatory liver diseases such as primary biliary cirrhosis and may mimic hepatocellular carcinoma. This diagnosis should be suspected in female w...
Source: Clinical Case Reports - Category: General Medicine Authors: Tags: CASE REPORT Source Type: research
We present two cases of ALS with PBC to explore the relationship between the two diseases from the immunological and mitochondrial aspects. Further attention should be given to immune-modulating therapy in ALS patients.
Source: Frontiers in Neurology - Category: Neurology Source Type: research
Authors: Milas GP, Karageorgiou V, Cholongitas E Abstract Introduction: Red cell distribution width to platelet ratio (RPR) may be a useful marker for the evaluation of liver fibrosis in chronic liver disease (CLD). We sought to investigate its value in fibrosis-related outcomes in a meta-analysis of diagnostic accuracy. Areas covered: We searched MEDLINE (1966-2019), (2008-2019), Cochrane Central Register of Controlled Trials (CENTRAL) (1999-2019), Google Scholar (2004-2019) and WHO (International Clinical Trials Register Platform) databases using a structured algorithm. The articles were assess...
Source: Expert Review of Gastroenterology and Hepatology - Category: Gastroenterology Tags: Expert Rev Gastroenterol Hepatol Source Type: research
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