Genetic polymorphism of vitamin D receptors and plasminogen activator inhibitor ‐1 and osteonecrosis risk in childhood acute lymphoblastic leukemia

ConclusionOsteonecrosis can develop early during the therapy of ALL. Older age and insufficient level of 25(OH)D were considered important risk factor for the development of osteonecrosis. PAT-1 and VDR gene polymorphism may be a genetic risk factor in its pathogenesis.

Source: Molecular Genetics & Genomic Medicine - May 27, 2021 Category: Genetics & Stem Cells Authors: Laila M. Sherief, Mohamed Beshir, Nermin Raafat, Elhamy R. Abdelkhalek, Wesam A. Mokhtar, Khaled M. Elgerby, Basma K. Soliman, Hosam E. Salah, Ghada A. Mokhtar, Naglaa M. Kamal, Heba ELsayed, Marwa Zakaria Tags: ORIGINAL ARTICLE Source Type: research