Identification of Novel, Immunogenic HLA ‐DR‐Presented Prevotella copri Peptides in Patients with Rheumatoid Arthritis

ConclusionsThe majority of our RA patients hadPc immune responses. The correlation of IgAPc antibodies, particularly toPc-p27, with ACPA supports the hypothesis that specific microbial antigens in the mucosa have a role in shaping or amplifying immune responses in RA joints.
Source: Arthritis and Rheumatology - Category: Rheumatology Authors: Tags: BRIEF REPORT Source Type: research

Related Links:

Best Pract Res Clin Rheumatol. 2021 Dec 31:101736. doi: 10.1016/j.berh.2021.101736. Online ahead of print.ABSTRACTRheumatoid arthritis (RA) can have various infectious mimics. As immunosuppressive agents used in treatment can aggravate the underlying infections, correct diagnosis of RA and ruling out infections is important. Numerous viral infections (Parvovirus B19, Hepatitis B, Hepatitis C, Chikungunya and other alphaviruses, human immunodeficiency virus (HIV) and various other viruses), mycobacterial infections (Poncet's disease, tubercular septic arthritis, and leprosy), bacterial arthritis, brucellosis and Lyme diseas...
Source: Cell Research - Category: Cytology Authors: Source Type: research
Am Fam Physician. 2021 Dec 1;104(6):589-597.ABSTRACTSeptic arthritis must be considered and promptly diagnosed in any patient presenting with acute atraumatic joint pain, swelling, and fever. Risk factors for septic arthritis include age older than 80 years, diabetes mellitus, rheumatoid arthritis, recent joint surgery, hip or knee prosthesis, skin infection, and immunosuppressive medication use. A delay in diagnosis and treatment can result in permanent morbidity and mortality. Physical examination findings and serum markers, including erythrocyte sedimentation rate and C-reactive protein, are helpful in the diagnosis but...
Source: American Family Physician - Category: Primary Care Authors: Source Type: research
More News: Arthritis | Lyme Disease | Rheumatoid Arthritis | Rheumatology