Vitamin B12 deficiency: Two warning signs on your legs to watch out for

VITAMIN B12 deficiency is increasingly common in older adults, especially as people around the age of 60 are prone to developing pernicious anaemia. Here the condition is detailed in depth.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news

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Int J Biol Macromol. 2021 Aug 19:S0141-8130(21)01755-4. doi: 10.1016/j.ijbiomac.2021.08.096. Online ahead of print.ABSTRACTProtein-ligand interactions play a significant role in all living organisms, thereby affecting the design and application of drugs and other biomaterials. The current study reports the binding of vitamin B12 to hemoglobin, employing optical spectroscopy and computational methods. It is observed that vitamin B12 quenched the intrinsic fluorescence of hemoglobin. The nature of quenching appears to be static according to the steady-state and time-resolved fluorescence measurements. The conformational chan...
Source: International Journal of Biological Macromolecules - Category: Biochemistry Authors: Source Type: research
VITAMIN B12 supplements are taken to correct a nutritional deficiency that may not be related to what you eat. It's fairly common for older adults to acquire an autoimmune condition called pernicious anaemia.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
VITAMIN B12 deficiency can be a commonplace for many. Even more so for anyone suffering with an autoimmune disease making absorbing the vitamin much harder. What are six symptoms indicating you may have this condition?
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
VITAMIN B12 aids the body in essential ways yet some people struggle to absorb the vitamin due to an underlying condition called pernicious anaemia. This can raise one's risk of developing B12 deficiency. Seeing these spots on your forearms could mean your diet needs to change or supplements are needed.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
VITAMIN B12 deficiency can produce changes to your physical and mental health. If you notice any of these six signs, it could indicate pernicious anaemia.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
CONCLUSIONS: we emphasize the importance of vitamin B12 supplementation during pregnancy and lactation. PMID: 33241939 [PubMed - as supplied by publisher]
Source: Nutricion Hospitalaria - Category: Nutrition Authors: Tags: Nutr Hosp Source Type: research
CONCLUSIONS: We report a case of pernicious anemia in which the first diagnosis suspicion was cold autoimmune hemolytic anemia (cAIHA) due to the presence of cold autoantibodies. A 47-year-old woman with a medical history of autoimmune thyroid disease came to the hospital with a clinical and serologic presentation of AIHA. However, because of determination of vitamin B12 (VB12) deficiency, she was finally diagnosed with megaloblastic anemia. In the acute period, the patient received short-term corticosteroid therapy and later VB12. The patient's hemoglobin level and general condition showed improvement. PMID: 33112632 ...
Source: Immunohematology - Category: Hematology Tags: Immunohematology Source Type: research
This study assessed whether GPCA-positive BMS (GPCA+BMS) patients had significantly higher frequencies of macrocytosis, anemia, hematinic deficiencies, and hyperhomocysteinemia than healthy control subjects or GPCA-negative BMS (GPCA-BMS) patients. METHODS: The mean corpuscular volume, blood hemoglobin (Hb), and serum iron, vitamin B12, folic acid, homocysteine, and GPCA levels were measured and compared between any two of three groups of 109 GPCA+BMS patients, 775 GPCA-BMS patients, and 442 healthy control subjects. RESULTS: We found that 109 GPCA+BMS patients had significantly higher frequencies of macrocytosis...
Source: J Formos Med Assoc - Category: General Medicine Authors: Tags: J Formos Med Assoc Source Type: research
Vitamin B12 is essential for the formation of red blood cells in the bone marrow. Its deficiency is mainly caused by gastrointestinal malabsorption and can result in pernicious anemia. Some oral signs and symptoms, such as burning sensation, glossitis with papillary atrophy, and areas of painful erythema, can be associated. Here, we report 3 cases of oral manifestations associated with vitamin B12 deficiency. The first patient was a 36-year-old male, and the other 2 were females, 61 and 70 years old.
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - Category: ENT & OMF Authors: Tags: 20190323 Source Type: research
Vitamin B12 (B12), also known as cobalamin, is a water-soluble vitamin. It is a cofactor in DNA synthesis and is involved in the metabolism of every cell of the human body, including the central nervous system. Those with a deficiency of B12 can present with peripheral neuropathy, pernicious anemia, or a cognitive disorder. Previous studies have revealed that a deficiency of B12 is associated with cognitive decline or Alzheimer disease. The data of 2991 people were evaluated from 2 years of the Korean Frailty and Aging Cohort Study, a nationwide multicenter survey. To assess cognitive function, a short form of the Korean ...
Source: Medicine - Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research
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