IJERPH, Vol. 18, Pages 5746: Incidence Rate and Risk Factors for Tuberculosis among People Living with HIV: A 2015 –2017 Cohort from Tashkent, Uzbekistan

IJERPH, Vol. 18, Pages 5746: Incidence Rate and Risk Factors for Tuberculosis among People Living with HIV: A 2015–2017 Cohort from Tashkent, Uzbekistan International Journal of Environmental Research and Public Health doi: 10.3390/ijerph18115746 Authors: Dilbar Sadirova Ruzanna Grigoryan Nargiza Parpieva Venera Barotova Aleksandr Trubnikov Lola Kalandarova Jamshid Gadoev Davron Mukhtarov Mariana Buziashvili Nestani Tukvadze Arax Hovhannesyan Andrei Dadu People living with the human immunodeficiency virus (PLHIV) have a higher risk of developing active tuberculosis (TB) disease, and TB remains a major cause of death in PLHIV. Uzbekistan is facing a substantial TB epidemic, which increases the risk of PLHIV developing active TB. Our retrospective cohort study aimed to evaluate the incidence rate and assess the risk factors for developing active TB among PLHIV. We collected secondary data extracted from medical charts of all patients, newly diagnosed at the AIDS Center in Tashkent, during the period of 2015–2017. The incidence rate of TB among PLHIV was 5.1 (95% CI: 4.5–6.0) per 1000 person/month. Adjusted regression analysis showed three major risk factors for TB, namely, being less than 15 years old (hazard ratio (HR) 5.83; 95% CI: 3.24–10.50, p value = 0.001),low CD4 count (adjusted hazard ratio(aHR) 21.0; 95% CI: 9.25–47.7, p value < 0.001), and antiretroviral therapy (ART) interruption/not receiving ART (aHR 5.57; 95% CI: ...
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Article Source Type: research