IJERPH, Vol. 18, Pages 5746: Incidence Rate and Risk Factors for Tuberculosis among People Living with HIV: A 2015 –2017 Cohort from Tashkent, Uzbekistan

IJERPH, Vol. 18, Pages 5746: Incidence Rate and Risk Factors for Tuberculosis among People Living with HIV: A 2015–2017 Cohort from Tashkent, Uzbekistan International Journal of Environmental Research and Public Health doi: 10.3390/ijerph18115746 Authors: Dilbar Sadirova Ruzanna Grigoryan Nargiza Parpieva Venera Barotova Aleksandr Trubnikov Lola Kalandarova Jamshid Gadoev Davron Mukhtarov Mariana Buziashvili Nestani Tukvadze Arax Hovhannesyan Andrei Dadu People living with the human immunodeficiency virus (PLHIV) have a higher risk of developing active tuberculosis (TB) disease, and TB remains a major cause of death in PLHIV. Uzbekistan is facing a substantial TB epidemic, which increases the risk of PLHIV developing active TB. Our retrospective cohort study aimed to evaluate the incidence rate and assess the risk factors for developing active TB among PLHIV. We collected secondary data extracted from medical charts of all patients, newly diagnosed at the AIDS Center in Tashkent, during the period of 2015–2017. The incidence rate of TB among PLHIV was 5.1 (95% CI: 4.5–6.0) per 1000 person/month. Adjusted regression analysis showed three major risk factors for TB, namely, being less than 15 years old (hazard ratio (HR) 5.83; 95% CI: 3.24–10.50, p value = 0.001),low CD4 count (adjusted hazard ratio(aHR) 21.0; 95% CI: 9.25–47.7, p value < 0.001), and antiretroviral therapy (ART) interruption/not receiving ART (aH...
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Article Source Type: research

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This article is republished from The Conversation under a Creative Commons license. Read the original article.
Source: IPS Inter Press Service - Health - Category: International Medicine & Public Health Authors: Tags: Global Headlines Health Source Type: news
ConclusionsDespite a good antiretroviral coverage, HIV infection is still diagnosed late in our country. The emphasis must be on the promotion of voluntary testing mainly among groups at high risk of infection.Key messagesMore active offer of HIV testing, by general practitioners, should play a crucial role in the early identification of HIV infections.Strategies such as use of preexposure prophylaxis should be developed to prevent HIV transmission among MSM.
Source: The European Journal of Public Health - Category: General Medicine Source Type: research
Spiegelman In Sub-Saharan Africa, communicable and other tropical infectious diseases remain major challenges apart from the continuing HIV/AIDS epidemic. Recognition and prevalence of non-communicable diseases have risen throughout Africa, and the reimagining of healthcare delivery is needed to support communities coping with not only with HIV, tuberculosis, and COVID-19, but also cancer, cardiovascular disease, diabetes, and depression. Many non-communicable diseases can be prevented or treated with low-cost interventions, yet implementation of such care has been limited in the region. In this Perspective piece, we...
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Perspective Source Type: research
Am J Trop Med Hyg. 2021 Oct 11:tpmd210899. doi: 10.4269/ajtmh.21-0899. Online ahead of print.ABSTRACTCOVID-19 has had considerable global impact; however, in sub-Saharan Africa, it is one of several infectious disease priorities. Prioritization is normally guided by disease burden, but the highly age-dependent nature of COVID-19 and that of other infectious diseases make comparisons challenging unless considered through metrics that incorporate life-years lost and time lived with adverse health. Therefore, we compared the 2020 mortality and disability-adjusted life-years (DALYs) lost estimates for malaria, tuberculosis, an...
Source: Am J Trop Med Hyg - Category: Infectious Diseases Authors: Source Type: research
CONCLUSIONS: Correcting for miscoding and misclassification of cause of death data can enhance the utility of the data for analyzing trends in HIV mortality and tracking progress toward the Sustainable Development Goal targets.PMID:34546661 | DOI:10.1002/jia2.25791
Source: Journal of the International AIDS Society - Category: Infectious Diseases Authors: Source Type: research
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Source: IPS Inter Press Service - Health - Category: International Medicine & Public Health Authors: Tags: COVID-19 Development & Aid Economy & Trade Featured Global Headlines Health Humanitarian Emergencies TerraViva United Nations COVAX COVID-19 vaccines TRIPS. WTO Source Type: news
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Source: IPS Inter Press Service - Health - Category: International Medicine & Public Health Authors: Tags: Development & Aid Economy & Trade Education Environment Global Headlines Health Human Rights TerraViva United Nations Source Type: news
[WHO] The World Health Organization and the Global Fund to Fight AIDS, Tuberculosis and Malaria signed a cooperation and financing agreement to implement 10 strategic initiatives to accelerate the end of AIDS, tuberculosis and malaria as epidemics and strengthen systems for health. This new agreement, which will cover the 2021-2023 implementation period, aims to address some of the persistent challenges that impede progress against the three diseases and protect hard-won gains from new pandemics like COVID-19.
Source: AllAfrica News: HIV-Aids and STDs - Category: Infectious Diseases Source Type: news
This article is republished from The Conversation under a Creative Commons license. Read the original article.
Source: IPS Inter Press Service - Health - Category: International Medicine & Public Health Authors: Tags: Headlines Health Poverty & SDGs Source Type: news
You don’t want to be a virus in Dr. David Ho’s lab. Pretty much every day since the COVID-19 pandemic began, Ho and his team have done nothing but find ways to stress SARS-CoV-2, the virus that causes the disease. His goal: pressure the virus relentlessly enough that it mutates to survive, so drug developers can understand how the virus might respond to new treatments. As a virologist with decades of experience learning about another obstinate virus, HIV, Ho knows just how to apply that mutation-generating stress, whether by starving the virus, bathing it in antibodies that disrupt its ability to infect cells, ...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized COVID-19 feature Genetics Magazine Source Type: news
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