Efficacy and Safety of Gout Prophylaxis and Therapy in CKD Efficacy and Safety of Gout Prophylaxis and Therapy in CKD

Is gout flare prophylaxis and treatment a safe and effective therapeutic strategy for patients with underlying chronic kidney disease?Arthritis Research &Therapy
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Rheumatology Journal Article Source Type: news

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Gout flare prophylaxis and therapy use in people with underlying chronic kidney disease (CKD) is challenging, given limited treatment options and risk of worsening renal function with inappropriate treatment d...
Source: Arthritis Research and Therapy - Category: Rheumatology Authors: Tags: Review Source Type: research
ABSTRACTObjectiveTo determine whether serum urate reduction with allopurinol lowers blood pressure (BP) in young adults and the mechanisms mediating this hypothesized effect.MethodsSingle ‐center, double‐blind, randomized, crossover clinical trial. Adults ages 18‐40 with baseline systolic BP (SBP) ≥ 120 and
Source: Arthritis and Rheumatology - Category: Rheumatology Authors: Tags: FULL LENGTH Source Type: research
This study examined the influence of uncontrolled gout on post-diagnosis comorbidities and medication use.MethodsThe Humana Research Database (2007 –2016, commercial insurance and Medicare) was searched (PearlDiver tool) for patients who had a gout diagnosis code, claims data for at least 6 months before and after diagnosis, and at least 90 days of continuous urate-lowering therapy within 1 year of diagnosis. Patients with controlled (all sUA measurements 
Source: Rheumatology and Therapy - Category: Rheumatology Source Type: research
Gout, a debilitating inflammatory arthritis, currently affects more than 9 million Americans. Hyperuricemia, the laboratory abnormality associated with the development of gout, also occurs in a significant number of patients with chronic kidney disease (CKD), a condition that affects approximately 14% of the US population. Several recent studies have attempted to provide a definitive link between the presence of hyperuricemia and progression of CKD; however, the treatment of asymptomatic hyperuricemia in CKD is not supported by recent randomized controlled trials.
Source: Seminars in Nephrology - Category: Urology & Nephrology Authors: Source Type: research
Abstract Gout is caused by monosodium urate crystal deposition in joints and tissues. Risk factors include male sex; obesity; hypertension; alcohol intake; diuretic use; a diet rich in meat and seafood; chronic kidney disease; a diet heavy in fructose-rich food and beverages; being a member of certain ethnic groups, including Taiwanese, Pacific Islander, and New Zealand Maori; and living in high-income countries. Gout is characterized by swelling, pain, or tenderness in a peripheral joint or bursa, including the development of a tophus. Diagnosis of gout can be made using several validated clinical prediction rule...
Source: American Family Physician - Category: Primary Care Authors: Tags: Am Fam Physician Source Type: research
AbstractA 66 years old Caucasian male presented with left elbow pain and swelling of 1 week duration. He denied any preceding trauma or fevers. He had a past history of diabetes mellitus, hypertension, hyperlipidemia and chronic kidney disease. 5 years ago, he was diagnosed with gout when he had podagra, which was treated with indomethacin. He did not take any urate ‐lowering medication. He reported multiple episodes of gout every year, mostly in the feet. On exam, he had swelling, tenderness, warmth, erythema and decreased range of motion of the left elbow. Synovial fluid aspiration was performed, and revealed monosodiu...
Source: Arthritis and Rheumatology - Category: Rheumatology Authors: Tags: CLINICAL IMAGE Source Type: research
AbstractObjectiveTo provide guidance for the management of gout including indications for and optimal use of urate ‐lowering therapy (ULT), treatment of gout flares, and lifestyle and other medication recommendations.MethodsFifty ‐seven patient intervention comparator outcome (PICO) questions were developed. This was followed by a systematic literature review including network meta‐analyses with rating of the available evidence according to GRADE methodology, and patient input. A group consensus process was used to compo se the final recommendations and grade their strength as strong or conditional.ResultsForty ‐tw...
Source: Arthritis and Rheumatology - Category: Rheumatology Authors: Tags: FULL LENGTH Source Type: research
ConclusionSeveral non ‐CV causes of mortality are increased in persons with gout, emphasizing the need for improved management of comorbidities.
Source: Arthritis and Rheumatology - Category: Rheumatology Authors: Tags: Original Article Source Type: research
This study investigates the association between exposure to urate-lowering drugs (ULDs) and progression and recovery from chronic kidney disease (CKD).
Source: Arthritis Research and Therapy - Category: Rheumatology Authors: Tags: Research article Source Type: research
ConclusionsSeveral non ‐CV causes of mortality are increased in persons with gout, highlighting the need for improved management of comorbidities.
Source: Arthritis and Rheumatology - Category: Rheumatology Authors: Tags: Full Length Source Type: research
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