Pharmacokinetics and safety of lefamulin after single intravenous dose administration in subjects with impaired ‐hepatic function

ConclusionLefamulin was generally well tolerated. Differences in lefamulin and BC-8041 pharmacokinetics were small, relative to the overall variability, and any changes appear to be compensated by increases in renal clearance and decreased protein binding.

Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - May 17, 2021 Category: Drugs & Pharmacology Authors: Wolfgang W. Wicha, Thomas C. Marbury, James A. Dowell, Jared L. Crandon, Cathie Leister, James Ermer, Steven P. Gelone Tags: EXPERIMENTAL THERAPEUTICS Source Type: research