Morphine enhances LPS-induced macrophage apoptosis through a PPAR γ-dependent mechanism

In conclusion, the findings of the present study indicated that morphine significantly promoted LPS-induced BMDM apoptosis and caspase-3/9 activation. These results suggested that the intrinsic pathway of apoptosis may be involved in the proapoptotic effects of morphine on LPS-stimulated BMDMs, which may be dependent, at least partially, on PPARγ activation.PMID:34007323 | PMC:PMC8120503 | DOI:10.3892/etm.2021.10146
Source: Experimental and Therapeutic Medicine - Category: General Medicine Authors: Source Type: research