Distinct fibroblasts in scars and regeneration

Curr Opin Genet Dev. 2021 May 19;70:7-14. doi: 10.1016/j.gde.2021.04.005. Online ahead of print.ABSTRACTThe skin is home to a collection of fibroblastic cell types from varying embryonic origins. These varying fibroblastic lineages display unique genetic programs and in vivo functions. Studying the diversity of fibroblastic cells is emerging as an important area for cutaneous biology, wound repair and regenerative medicine. In this mini-review we discuss the distinct embryonic origins, microenvironments, and transcriptomic profiles of fibroblastic lineages, and how these varying lineages shape the skin's wound response across injury depths, anatomic locations, and developmental time to promote either scarring or regeneration. We outline how the development of single cell sequencing has led to our improved understanding of fibroblastic lineages at the molecular level and discuss existing challenges and future outlook on developing regenerative therapies that are based on this emerging field of eclectic fibroblasts.PMID:34022662 | DOI:10.1016/j.gde.2021.04.005
Source: Current Opinion in Genetics and Development - Category: Genetics & Stem Cells Authors: Source Type: research