Polymorphisms in < em > CRYAA < /em > Promoter with Susceptibility to Cataract: A Meta-Analysis

Conclusion: Our meta-analysis indicated that rs3761382 and rs13053109 polymorphisms of CRYAA may not be associated with susceptibility to cataracts. Individuals carrying mutant genotype of rs7278468 polymorphism are associated with a significantly decreased cataract risk.Abbreviations: CC: Congenital cataract; ARC: Age-related cataract; SNPs: single nucleotide polymorphisms; NOS: Newcastle-Ottawa Scale; HWE: Hardy-Weinberg equilibrium; OR: odds ratio; CI: confidence interval; qPCR: quantitative polymerase chain reaction; NO: nuclear opalescence; NC: nuclear color.PMID:34010109 | DOI:10.1080/08820538.2021.1903943
Source: Seminars in Ophthalmology - Category: Opthalmology Authors: Source Type: research