Expression of gilt acts as a positive regulator of mouse hematopoietic progenitor cells

Blood Cells Mol Dis. 2021 Apr 30;90:102574. doi: 10.1016/j.bcmd.2021.102574. Online ahead of print.ABSTRACTGamma interferon inducible lysosomal thiol reductase (GILT), is known to be involved in immunity, but its role in hematopoiesis has not been previously reported. Herein, we demonstrate using gilt knockout (-/-) mice that loss of gilt associates with decreased numbers and cycling status of femoral hematopoietic progenitor cells (CFU-GM, BFU-E, and CFU-GEMM) with more modest effects on splenic progenitor cells. Thus, GILT is associated with positive regulation of hematopoietic progenitor cells in mice, mainly in bone marrow.PMID:34015674 | DOI:10.1016/j.bcmd.2021.102574

Source: Blood Cells, Molecules and Diseases - May 20, 2021 Category: Hematology Authors: Hal E Broxmeyer Scott Cooper Janice S Blum Source Type: research