Metaplastic Breast Cancer: Clinical Overview and Molecular Aberrations for Potential Targeted Therapy

Abstract Metaplastic breast cancer is a rare subtype of invasive mammary carcinoma, with an aggressive behavior and usually poor outcome. Responses to systemic chemotherapy are suboptimal compared to patients with standard invasive ductal carcinoma. Limited data are available in regards to best treatment modalities, including chemotherapy. This review gives an overview of metaplastic breast cancer and its clinical and pathologic characteristics, in addition to treatment strategies, clinical trials, and future directions.
Source: Current Oncology Reports - Category: Cancer & Oncology Source Type: research