VIP reduction in the pancreas of F508del homozygous CF mice and early signs of Cystic Fibrosis Related Diabetes (CFRD)

Vasoactive intestinal peptide (VIP), which was discovered in the 1970s by Said and Mutt, is a 28-residue polypeptide that was first isolated from porcine small intestine as a vasodilatory peptide [1,2]. It belongs to a superfamily of brain-gut peptide hormones structurally related to secretin, glucagon and pituitary adenylyl cyclase-activating peptide (PACAP) [2,3]. VIP mediates its functions through the G protein-coupled receptors VPAC1 (VIP receptor type 1) or VPAC2 (VIP receptor type 2) [4]. VIP is expressed in the central and peripheral nervous systems as well as in the digestive, respiratory, reproductive and cardiovascular systems as a neurotransmitter or neuromodulator [4,5].
Source: Journal of Cystic Fibrosis - Category: Respiratory Medicine Authors: Tags: Original Article Source Type: research