Toxicity and pharmacokinetics of actinomycin-D and vincristine in children and adolescents: Children ’s Oncology Group Study ADVL06B1

Conclusion: Pharmacokinetics of both drugs were highly variable. For actinomycin-D, there was no correlatio n between demographic or pharmacokinetic parameters and target toxicities. For vincristine, the correlations of age and BSA and neuropathy are confounded by the correlation between age and BSA in children and the ability to ascertain neuropathy in infants. Variability may be attributed to dose reduc tions and capped doses for both drugs. Investigation of BSA-based dosing in young children is warranted to decrease variability of exposure.
Source: Cancer Chemotherapy and Pharmacology - Category: Cancer & Oncology Source Type: research