Determination of incompatibility group plasmids and copy number of the < em > bla < /em > < sub > NDM-1 < /sub > gene in carbapenem-resistant < em > Klebsiella pneumoniae < /em > strains recovered from different hospitals in Kerman, Iran

Conclusion. The spread of NDM-1-producing K. pneumoniae strains that carry several plasmid replicon types increases the chance of horizontal transfer of antibiotic resistance genes in hospital settings. In this study, 10 different replicon types were identified. We could not find any relationship between the increase of MIC levels to imipenem and the copy numbers of bla NDM-1. Therefore, due to the identification of different replicon types in this study, the type and genetic characteristics of bla NDM-1-carrying plasmids, and other factors such as antibiotic selective pressure, probably affect the copy number of bla NDM-1 and change the MIC level to imipenem.PMID:33999798 | DOI:10.1099/jmm.0.001361
Source: Journal of Medical Microbiology - Category: Microbiology Authors: Source Type: research