Curative Therapy Choice and Lesion Detection by 18F-DCFPyL and Multiparametric MRI in Biochemically Recurrent Prostate Cancer

Conclusions: 18F-DCFPyL detected more lesions than mpMRI within the same FOV across all therapy groups with the most lesions in those who had undergone both prostatectomy and radiation (89 lesions). MRI detected more lesions than 18F-DCFPyL in the prostate bed, primarily in the surgical and radiotherapy groups (35 and 36 lesions, respectively) with the least number of lesions seen in the dual therapy group (24 lesions). Concordance rates between the two modalities was comparably modest among the treatment groups (20.8% for surgery, 33.3% for radiation and 21.2% for both.) Curative therapy method (surgery, radiation or both) appears to influence lesion detection for 18F-DCFPyL and MRI in patients with BCR.
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Prostate/GU Source Type: research

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Maybe one of your patients could benefit from the late-phase clinical trials that are currently recruiting men with various stages of prostate cancer.Medscape Medical News
Source: Medscape Hematology-Oncology Headlines - Category: Cancer & Oncology Tags: Hematology-Oncology News Source Type: news
In conclusion, a solitary thickened extraocular eye muscle should be recognized in time and examined further.Case Rep Ophthalmol 2021;12:870 –874
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Oligometastatic prostate cancer (PCa) can be defined as cancer with a limited number of metastases, typically fewer than 5 lesions, and involves lesions contained within the axial versus the appendicular skeleton. Patients can present with de novo oligometastatic, oligorecurrent, or oligoprogressive PCa. Oligometastatic PCa patients demonstrate considerable improvements in survival outcomes, with a better prognosis than patients with extensive metastatic disease. However, the management of patients that present with nonsymptomatic oligometastatic PCa remains difficult. In the oligometastatic setting, the benefit of local t...
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Source: Current Issues in Molecular Biology - Category: Molecular Biology Authors: Source Type: research
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Source: Journal of Vascular and Interventional Radiology : JVIR - Category: Radiology Authors: Tags: Letter to the Editor Source Type: research
The use of brachytherapy for the definitive treatment of localized prostate cancer has been established for over four decades (1). Therapy may be delivered using either permanent seed low dose rate (LDR) or high dose rate (HDR) technique. Both techniques are recommended in the ASCO/CCO joint guidelines (2), and data suggests comparable oncologic outcomes. Brachytherapy may be used as monotherapy for low risk and selected intermediate risk patients or in conjunction with external beam radiation therapy (EBRT) for unfavorable intermediate and high risk patients.
Source: Brachytherapy - Category: Cancer & Oncology Authors: Source Type: research
Effective in situ cancer vaccines require both a means of tumor cell death and a source of adjuvant to activate local dendritic cells. Studies have shown that the use of radiotherapy (RT) to induce tumor cell death and anti-CD40 to activate dendritic cells can result in in situ vaccination in animal models. Here, investigations are carried out on potential strategies to enhance such in situ vaccination. Strategies investigated include the use of smart immunogenic biomaterials (IBM) loaded with anti-CD40 in different tumor types including immunologically cold tumors like pancreatic and prostate tumors. The use of downstream...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
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