Curative Therapy Choice and Lesion Detection by 18F-DCFPyL and Multiparametric MRI in Biochemically Recurrent Prostate Cancer

Conclusions: 18F-DCFPyL detected more lesions than mpMRI within the same FOV across all therapy groups with the most lesions in those who had undergone both prostatectomy and radiation (89 lesions). MRI detected more lesions than 18F-DCFPyL in the prostate bed, primarily in the surgical and radiotherapy groups (35 and 36 lesions, respectively) with the least number of lesions seen in the dual therapy group (24 lesions). Concordance rates between the two modalities was comparably modest among the treatment groups (20.8% for surgery, 33.3% for radiation and 21.2% for both.) Curative therapy method (surgery, radiation or both) appears to influence lesion detection for 18F-DCFPyL and MRI in patients with BCR.

Source: Journal of Nuclear Medicine - May 18, 2021 Category: Nuclear Medicine Authors: Lindenberg, L., Mena, E., Turkbey, B., Shih, J., Bergvall, E., Adler, S., Lin, F., Ton, A., McKinney, Y., Citrin, D., Madan, R., Dahut, W., Choyke, P. Tags: Prostate/GU Source Type: research