Melanoma and Li-Fraumeni syndrome - family history not essential for screening recommendation

Clin Exp Dermatol. 2021 May 19. doi: 10.1111/ced.14748. Online ahead of print.ABSTRACTLi-Fraumeni Syndrome (LFS) is a recognised cancer predisposition syndrome associated with early onset of multiple cancer types. It was first described in 1969 following the identification of two soft tissue sarcomas in five families with the index case presenting with rhabdomyosarcoma in childhood.1 The tumour spectrum classically includes a range of soft tissue sarcomas, bone tumours, haematological malignancies, breast cancer and adrenal cortical cancer.PMID:34008262 | DOI:10.1111/ced.14748
Source: Clinical Genitourinary Cancer - Category: Cancer & Oncology Authors: Source Type: research