Unlikely that topical pimecrolimus associated with increased risk of cancer

The topical medicine pimecrolimus to treat eczema (atopic dermatitis or AD) in children appears unlikely to be associated with increased of risk of cancer based on how it was used in group of children followed for 10 years, according to an article.
Source: ScienceDaily Headlines - Category: Science Source Type: news

Related Links:

Regul Toxicol Pharmacol. 2021 Sep 24;126:105048. doi: 10.1016/j.yrtph.2021.105048. Online ahead of print.ABSTRACTHexavalent chromium (Cr(VI)) compounds have been studied extensively and several agencies have described their toxicological profile. In the past, personnel of the Dutch Ministry of Defence may have been exposed to Cr(VI) during maintenance activities. To investigate if this exposure may have caused irreversible adverse health effects, the Dutch National Institute for Public Health and the Environment (RIVM) summarized all available knowledge from previous evaluations. This information was complemented with a sc...
Source: Regulatory Toxicology and Pharmacology : RTP - Category: Toxicology Authors: Source Type: research
(Northwestern University) Itch can be as debilitating as chronic pain. But it's a hard symptom to measure -- particularly for the 10 million U.S. children with atopic dermatitis, also known as eczema. But now there is a soft, wearable sensor that quantifies itch by measuring scratching when placed on the hand. It allows parents and doctors to track how well itch is being controlled in patients, monitor treatment response and early signs of worsening disease.
Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news
AbstractEczematous drug eruptions are a heterogenous group of skin reactions that resemble eczema both clinically and histologically. We reviewed the literature and cataloged the systemically administered medications that cause these eruptions, along with their characteristic clinical presentations. We identified three primary pathophysiologic etiologies: (1) cutaneous immunomodulation, (2) skin dehydration, and (3) delayed hypersensitivity. Notably, eczematous eruptions caused by altered immunity in the skin may be increasing in incidence as some responsible drugs, in particular biologic therapies (such as tumor necrosis ...
Source: American Journal of Clinical Dermatology - Category: Dermatology Source Type: research
AbstractAtopic dermatitis (AD) is a chronic inflammatory skin disease with an estimated prevalence of 10 –15% in children and 2–10% in adults. Clinically, there is notable phenotypic variability driven by a complex interaction between genetics, immune function, and the environment. Impairment of the skin barrier plays a significant role in the pathogenesis of AD. The apparent beneficial effect of s unlight in patients with atopic eczema is questioned due to its capacity to disrupt the skin barrier and generate free radicals that can damage proteins, lipids, and DNA. The sum of the external factors that an indiv...
Source: Dermatology and Therapy - Category: Dermatology Source Type: research
Solanum nigrum Linne improves DNCB‑induced atopic dermatitis‑like skin disease in BALB/c mice. Mol Med Rep. 2020 Jul 28;: Authors: Hong S, Lee B, Kim JH, Kim EY, Kim M, Kwon B, Cho HR, Sohn Y, Jung HS Abstract The present study aimed to investigate the effects of Solanum nigrum Linne (SNL) in a model of 1‑chloro‑2,4‑dinitrobenzene (DNCB)‑induced atopic dermatitis (AD) and in TNF‑α/IFN‑γ‑stimulated HaCaT cells. AD is a chronic inflammatory skin disease and is characterized by erythema, edema, increased pruritus and eczema. Steroids are most commonly used for anti...
Source: Molecular Medicine Reports - Category: Molecular Biology Tags: Mol Med Rep Source Type: research
Malassezia is the most prevalent fungus identified in the human skin microbiota; originally described at the end of the nineteenth century, this genus is composed of at least 14 species. The role of Malassezia on the skin remains controversial because this genus has been associated with both healthy skin and pathologies (dermatitis, eczema, etc.). However, with the recent development of next-generation sequencing methods, allowing the description of the fungal diversity of various microbiota, Malassezia has also been identified as a resident fungus of diverse niches such as the gut or breast milk. A potential role for Mala...
Source: Frontiers in cellular and infection microbiology - Category: Microbiology Source Type: research
There’s no faster way to purify your body of viruses, bacteria and fungi — and at the same time ramp up your immune system — than a 125-year-old “cure” banned by the FDA. I’m talking about ozone therapy — and it’s not just good for cleansing your body. You see, ozone — a special “energized” kind of oxygen — can help heal almost any condition. Despite being banned by the FDA back in the 1940s, after more than 60 years of successful use, ozone therapy has saved millions of lives in countries where it has become a commonplace medical treatment. In count...
Source: Al Sears, MD Natural Remedies - Category: Complementary Medicine Authors: Tags: Health Source Type: news
agh N Abstract : The aim of this study was to conduct 3 literature reviews to examine the impact of atopic dermatitis (AD) and chronic hand eczema (CHE) on health-related quality of life (HRQoL) compared with other chronic conditions by comparing reported utility scores of 4 commonly used generic HRQoL instruments. A systematic search was performed using PubMed, ScienceDirect, MEDLINE, EMBASE, Health Technology Assessment database, and ScHARRHUD. Inclusion criteria included, but were not limited to, patients of any age, studies from any location, publications reporting utility data based on EuroQoL 5 dimensions, t...
Source: Dermatitis - Category: Dermatology Authors: Tags: Dermatitis Source Type: research
Conditions:   Eczema/Atopic Dermatitis;   Lung Cancer Intervention:   Sponsors:   Boston Children’s Hospital;   Pfizer Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
More News: Cancer | Cancer & Oncology | Children | Dermatitis | Dermatology | Eczema | Elidel | Science