Old And New Oral Anticoagulants In Management Of Atrial Fibrillation: A Double-Edged Sword For Women.

Old And New Oral Anticoagulants In Management Of Atrial Fibrillation: A Double-Edged Sword For Women. Curr Vasc Pharmacol. 2015 Feb 16; Authors: Stefania B, Valeria R, Marco P, Laura N, Patrizia F, Flavia F Abstract Atrial fibrillation (AF), one of the most prevalent supra-ventricular arrhythmia in adults, is related to a substantial increase in the risk of thromboembolic events requiring tailored preventive strategy. In AF, antithrombotic therapy should be individualized according to a careful decision-making process, taking in account the likely concomitant presence of risk factors for stroke and bleeding. Anticoagulation management is particularly challenging in women with AF, to the extent that female sex is incorporated in commonly used stratification schemes for both thromboembolic and bleeding risk evaluation. Nevertheless, gender-based differences on the efficacy and safety of either "old" (i.e. vitamin K antagonist) or "new" oral anticoagulants (i.e. direct thrombin inhibitors and activated factor X inhibitors) are not conclusive and not always reported. This review aims to analyse the literature on sex differences in AF anticoagulation management. We focus on safety data, bleeding complications and specific haemostatic mechanisms currently under investigation, which could account for observed disparities among sexes. Moreover, details on sex difference in response to anticoagulant treatment will be discussed. Comparing old a...
Source: Current Vascular Pharmacology - Category: Drugs & Pharmacology Authors: Tags: Curr Vasc Pharmacol Source Type: research

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ConclusionHemiplegic spontaneous cervical EDH occurs very rarely. It is often misdiagnosed as ischemic stroke and is likely to be administered with thrombolytic agents, making the patient's symptoms worse. Early diagnosis and rapid management of cervical EDH increase the likelihood of complete recovery of the patient's symptoms. Therefore, if there are unilateral weakness and neck pain without cranial nerve dysfunction and there is no evidence of stroke in the brain imaging, spinal EDH should be considered.
Source: Interdisciplinary Neurosurgery - Category: Neurosurgery Source Type: research
Publication date: Available online 20 August 2019Source: LWTAuthor(s): Jing Peng, Xu Yin, Shunshan Jiao, Kangli Wei, Kang Tu, Leiqing PanAbstractA hybrid drying method for high moisture foods (apple slices) was proposed in this study. Air jet impingement (AJI) was applied as the 1st stage drying method for fresh samples, and hot air-assisted radio frequency (HA-RF) was used for the 2nd drying stage to reduce the moisture content of semi-dried samples to the target level (
Source: LWT Food Science and Technology - Category: Food Science Source Type: research
Publication date: October 2019Source: Fish &Shellfish Immunology, Volume 93Author(s): Pan Wu, Weiguang Yang, Yuying Dong, Yanling Wang, Ying Zhang, Xuejun Zou, Hui Ge, Dongxue Hu, Yubo Cui, Zhaobo ChenAbstractApplication of traditional bait in aquaculture caused environment pollution and disease frequent occurrence. Residual coconut could be re-utilized to culture Spinibarbus sinensis as dietary supplement. Therefore, a novel integrated system of the improvement of yield, antioxidant and nonspecific immunity of Spinibarbus sinensis by dietary residual coconut was proposed and investigated. Spinibarbus sinensis could gr...
Source: Fish and Shellfish Immunology - Category: Biology Source Type: research
In this study, polydopamine (PDA) coated chitosan/calcium pyrophosphate hybrid microflowers (PDA@CS-CaP) were prepared using a facile approach and evaluated as a hemostatic agent. The surface morphology and elements, chemical groups, porous structure, thermostability, zeta potential, as well as surface wettability were systematically characterized by scanning electron microscopy (SEM), X-ray photoelectron spectroscopy (XPS), Fourier transform infrared spectroscopy (FTIR), N2 adsorption-desorption, thermogravimetry (TGA) and contact angle apparatus. Due to the synergistic effects of the high hydrophilicity (water contact an...
Source: Carbohydrate Polymers - Category: Biomedical Science Source Type: research
Publication date: Available online 14 August 2019Source: Colloids and Surfaces A: Physicochemical and Engineering AspectsAuthor(s): O. Gmach, A. Bertsch, C. Bilke-Krause, U. KulozikAbstractThe aim of this study was to investigate the effect of oil type, i.e. sunflower, rapeseed, peanut and corn oil on the emulsification effect. Knowledge about the impact of the different oils on the emulsification process in a head-to-head comparison is lacking. The hypothesis was that various oils as such or with their special compositions of by-products will have an impact on the properties of the resulting emulsion. As a novel aspect, a...
Source: Colloids and Surfaces A: Physicochemical and Engineering Aspects - Category: Chemistry Source Type: research
Publication date: Available online 19 August 2019Source: Regulatory Toxicology and PharmacologyAuthor(s): M. Clemente, M.D. Miguel, K.B. Felipe, C. Gribner, P.F. Moura, A.G.R. Rigoni, L.C. Fernandes, J.L.S. Carvalho, I. Hartmann, M.T. Piltz, R. Henneberg, D.P. Montrucchio, O.G. MiguelAbstractNasturtium officinale (watercress) is a perennial dicotyledonous plant, rich in vitamins, minerals and chemical compounds. The leaves of this plant, which contain glucosinolate, are used for its diuretic and hypoglycemic effects. The purpose of the study was to investigate the safety of the standardized extract of Nasturtium officinale...
Source: Regulatory Toxicology and Pharmacology - Category: Toxicology Source Type: research
Conclusion: The accuracy of preoperative histologic examination was moderate. Our findings recommend cautious clinical decision making and limiting hysterectomy to women who do not respond to other therapeutic measures. PMID: 31423519 [PubMed - in process]
Source: Saudi Medical Journal - Category: Middle East Health Tags: Saudi Med J Source Type: research
Condition:   The Effect of Obesity on Recurrent Stroke Intervention:   Diagnostic Test: Obesity assessment Sponsor:   Ege University Completed
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Stroke;   Silent Cerebral Infarct Intervention:   Device: Sentinel and Spider Sponsors:   Imperial College London;   St Mary's Hospital, London Suspended
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
This study was designed to examine whether valsartan or fluvastatin can reduce the risk of non-permanent AF in patients with hypertension.Methods/designThe VF-HT-AF study is a multicenter, randomized, open-label, four-arm parallel group study with comparative evaluation of valsartan and fluvastatin as upstream therapies for the treatment of non-permanent AF complicated by hypertension. The primary outcome measure is change in the development of paroxysmal AF into persistent or permanent AF, the development of persistent AF to permanent AF, and change in incidence of overall and persistent AF recurrence, as evaluated by 7-d...
Source: Trials - Category: Journals (General) Authors: Source Type: research
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