Pre-operative N-terminal pro-B-type natriuretic peptide for prediction of acute kidney injury after noncardiac surgery: A retrospective cohort study
BACKGROUND
Acute kidney injury (AKI) is associated with poor outcomes after noncardiac surgery. Whether pre-operative N-terminal pro-B-type natriuretic peptide (NT-proBNP) predicts AKI after noncardiac surgery is unclear.
OBJECTIVE
To investigate the predictive role of pre-operative NT-proBNP on postoperative AKI.
DESIGN
Retrospective cohort study.
SETTING
Nanfang Hospital, Southern Medical University, China.
PATIENTS
Adult patients who had a serum creatinine and NT-proBNP measurement within 30 pre-operative days and at least one serum creatinine measurement within 7 days after noncardiac surgery between February 2008 and May 2018 were identified.
MAIN OUTCOME MEASURES
The primary outcome was postoperative AKI, defined by the kidney disease: improving global outcomes creatinine criteria.
RESULTS
In all, 6.1% (444 of 7248) of patients developed AKI within 1 week after surgery. Pre-operative NT-proBNP was an independent predictor of AKI after adjustment for clinical variables (OR comparing top to bottom quintiles 2.29, 95% CI, 1.47 to 3.65, P
Source: European Journal of Anaesthesiology - Category: Anesthesiology Tags: Perioperative risk management Source Type: research