Differences in the Expression of KIR, ILT Inhibitory Receptors, and VEGF Production in the Induced Decidual NK Cell Cultures of Fertile and RPL Women

CONCLUSIONS: A combination of hypoxia, IL-15, and AZA promotes the conversion of pbNK into idNK cells CD56+CD16--expressing KIR receptors and produces VEGF. Alterations in KIR2DL1 and ILT-2 expression as well as impaired VEGF production were associated with RPL. SC affects NKG2A expression on RPL idNK cells. SC had no effect on VEGF release or idNK cell apoptosis.PMID:33997038 | PMC:PMC8112925 | DOI:10.1155/2021/6673427

Source: Biomed Res - May 17, 2021 Category: Research Authors: Monika Kniotek Aleksander Roszczyk Micha ł Zych Monika Szafarowska Ma łgorzata Jerzak Source Type: research