Expression of activated integrin β7 in multiple myeloma patients

In this study, we performed flow cytometry analysis of the expression of activated integrin β7 in bone marrow cells from 137 symptomatic MM patients. In 60/137 (44%) MM patients, activated integrin β7 was detected in most MM cells (> 80% of MM cells were in the positive gate). Activated integrin β7 was highly expressed in MM cells even in heavily treated patients. It also showed high expression in many CD38lo/-CD138-CD19+B cells, which reportedly include clonotypic B cells, in the bone marrow of MM patients. Taken together, these results suggest that CAR T-cell therapy targeting activated integrin β7 has the potential to benefit many patients with relapsed or refractory MM.PMID:33999338 | DOI:10.1007/s12185-021-03162-2

Source: International Journal of Hematology - May 17, 2021 Category: Hematology Authors: Naoki Hosen Satoshi Yoshihara Hiroyuki Takamatsu Masaki Ri Yasuyuki Nagata Hiroshi Kosugi Yoshimitsu Shimomura Ichiro Hanamura Shigeo Fuji Koichiro Minauchi Junya Kuroda Rikio Suzuki Noriko Nishimura Nobuhiko Uoshima Hirohisa Nakamae Yawara Kawano Ishikaz Source Type: research