Endothelial genetic deletion of CD147 induces changes in the dual function of the blood-brain barrier and is implicated in Alzheimer's disease

CONCLUSIONS: Our findings suggested that targeting CD147 in BECs may represent a novel therapeutic strategy, which promoted the design of future experimental investigations and the mechanistic understanding of neurodegenerative diseases.PMID:33987940 | DOI:10.1111/cns.13659

Source: CNS Neuroscience and Therapeutics - May 14, 2021 Category: Neuroscience Authors: Hao Wang Jian-Jun Lv Yu Zhao Hao-Lin Wei Tian-Jiao Zhang Hai-Jiao Yang Zhi-Nan Chen Jian-Li Jiang Source Type: research