Dupilumab rapidly improves asthma control in predominantly anti ‐IL5/IL5R pretreated Austrian real‐life severe asthmatics

This is a real-life study that shows that dupilumab is effective and safe in Austrian real-life severe asthmatics. It rapidly improved asthma control. These improvements are comparable to previous randomized controlled trials. AbstractDupilumab is a monoclonal antibody against the IL-4 receptor alpha which has shown efficacy in T2 high severe asthmatics in phase 3 randomized controlled trials. The purpose of this real-life study is to demonstrate the real-life effectiveness of dupilumab in Austrian severe asthma patients. We retrospectively analyzed all patients receiving dupilumab at our severe asthma clinic. Thirteen patients have so far received dupilumab at our center. The primary outcome, asthma control questionnaire 6-item scale at 2 weeks, improved by 0.57 points (p = .014), which is statistically and clinically significant. Similarly, the asthma control test at 4 weeks improved by 3.91 points (p = .024), also statistically and clinically significant. Improvements in forced expiratory volume in 1 s at 2 weeks were neither statistically, nor clinically significant. Improvements at 4 weeks (+220 ml,p = .041), and 3 months (+229 ml,p = .006), were statistically significant and clinically borderline significant. No severe adverse events or hypereosinophilia were observed. No adverse events led to treatment discontinuation. Most patients (85%) had previously received monoclonal antibody treatment for severe asthma. Previous m onoclonal antibody treatm...
Source: Immunity, Inflammation and Disease - Category: Allergy & Immunology Authors: Tags: COMMENTARY Source Type: research