Diet-Dependent Sex Differences in the Response to Vertical Sleeve Gastrectomy

Am J Physiol Endocrinol Metab. 2021 May 17. doi: 10.1152/ajpendo.00060.2021. Online ahead of print.ABSTRACTNearly 80% of patients that receive bariatric surgery are women, yet mechanistic pre-clinical studies have focused on males. The goal of this study was to determine the metabolic impact of diet- and surgery-induced weight loss in males, females, and ovariectomized females. Male and female mice were fed a 60% high-fat (HFD) diet before undergoing either vertical sleeve gastrectomy (VSG) or sham surgery. Mice either remained on HFD or were switched to a standard chow diet post-surgically. When maintained on HFD, both males and females decreased fat mass and improved oral glucose tolerance after VSG. After dietary intervention, additional adiposity was lost in both surgical groups. Ovariectomized females had a blunted decrease in fat mass on a HFD, but lost significant adiposity after dietary intervention. Energy expenditure was only impacted by dietary but not surgical intervention across all groups. Males decreased hepatic triglyceride levels after VSG, which was further decreased after dietary intervention. Intact and ovariectomized females had a blunted decrease in hepatic triglycerides after surgical intervention but a significant decrease after dietary intervention. The more pronounced effect of surgery on hepatic lipids in males was strongly associated with changes in expression of hepatic microRNAs and genes that have previously been linked to hepatic lipid regulati...
Source: American Journal of Physiology. Endocrinology and Metabolism - Category: Physiology Authors: Source Type: research