Mitochondrial DNA Polymorphisms and Biogenesis Genes in Primary and Metastatic Uveal Melanoma Cell Lines

Uveal melanoma (UM) is the most common primary intraocular malignancy in adults [1]. Although UMs can be associated with any uveal tract tissue, the most common locations are within the choroid and ciliary body (97 –98% of all UMs) and the remaining occur in the iris (2–3%). Irradiation with either proton beam or radioactive plaque is the primary treatment modality in UM patients and is usually associated with preservation of the eye. In a minority of patients, enucleation is necessary. However, overall su rvival with this tumor is still poor with a 5-year survival rate of only 82% [2].
Source: Cancer Genetics and Cytogenetics - Category: Genetics & Stem Cells Authors: Source Type: research