Vitamine B12 deficiency in children: a diagnostic challenge
We report six paediatric patients with different aetiologies of vitB12 deficiency ranging from a subtle to a more overt presentation. VitB12 deficiency is a diagnostic challenge due to the lack of consensus on normal values of vitB12 and its co-markers (folate, holotranscobalamin, methylmalonic acid, homocysteine) and the lack in specificity and sensitivity of the serum vitB12 analysis. All cases were treated with parenteral vitB12. Last decades, evidence supporting high dose oral treatment being as effective as the intramuscular (IM) therapy, also in children, is growing.PMID:33639702
Source: Acta Gastro-Enterologica Belgica - Category: Gastroenterology Authors: J Van Vlaenderen J Christiaens M Van Winckel R De Bruyne S Vande Velde S Van Biervliet Source Type: research
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