Routine first-trimester combined screening for pre-eclampsia: pregnancy-associated plasma protein-A or placental growth factor?

Ultrasound Obstet Gynecol. 2021 May 16. doi: 10.1002/uog.23669. Online ahead of print.ABSTRACTOBJECTIVE: To compare the screening performance of serum pregnancy-associated plasma protein-A (PAPP-A) versus placental growth factor (PlGF) in routine first trimester combined screening for preeclampsia (PE), small for gestational age (SGA) birth and trisomy 21.METHODS: Retrospective study nested in pregnancy cohorts undergoing first trimester combined screening for PE and trisomy 21 using the Fetal Medicine Foundation (FMF) algorithm based on maternal characteristics, nuchal translucency, PAPP-A, free beta-human chorionic gonadotropin, blood pressure and uterine artery Doppler. Women at high-risk for preterm PE (≥1 in 50) received 150 mg aspirin, serial fetal growth scans at 28 and 36 weeks and were offered elective birth from 40 weeks of gestation. PlGF was retrospectively quantified in stored surplus first-trimester serum samples. The performance of combined first trimester screening for PE, SGA and trisomy 21 using either PAPP-A or PlGF was calculated.RESULTS: Maternal serum PAPP-A was assayed in 1094 women including 82 with PE, 111 with SGA
Source: The Ultrasound Review of Obstetrics and Gynecology - Category: Radiology Authors: Source Type: research

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AbstractStudy questionAre women presenting with bleeding in the first trimester of pregnancy at a higher risk for perinatal complications later in pregnancy?Summary answerWomen presenting with bleeding in the first trimester of pregnancy are more likely to experience perinatal and neonatal morbidity in pregnancy.What is known alreadyObservational studies and a previously reported systematic review showed that women who experienced threatened miscarriage are more likely to have still birth, intra uterine growth restriction (IUGR), low birth weight, pre-eclampsia, placental abruption, placenta previa, preterm labour, preterm...
Source: Human Reproduction - Category: Reproduction Medicine Source Type: research
The objective of this study is to examine the potential improvement in screening for PE with delivery at
Source: The Ultrasound Review of Obstetrics and Gynecology - Category: Radiology Authors: Source Type: research
Ultrasound Obstet Gynecol. 2021 Mar 1. doi: 10.1002/uog.23623. Online ahead of print.ABSTRACTOBJECTIVE: There are two objectives to the study. First, to examine the value of uterine artery pulsatility index (UtA-PI) at 19-24 weeks' gestation in the prediction of subsequent development of preeclampsia (PE) and compare the performance of screening between the use of first, fixed cut-offs of UtA-PI, second, percentile cut-offs in UtA-PI adjusted for gestational age, third, competing risks model combining maternal demographic characteristics and medical history with UtA-PI, and fourth, competing risks model combining maternal ...
Source: The Ultrasound Review of Obstetrics and Gynecology - Category: Radiology Authors: Source Type: research
DiscussionThis review will assess whether current published data reporting either a single or combination of tests in late pregnancy can accurately predict adverse pregnancy outcome(s) associated with placental dysfunction. Accurate prediction could allow targeted management and possible intervention for high-risk pregnancies, ultimately avoiding adverse outcomes associated with placental disease.Systematic review registrationPROSPEROCRD42018107049
Source: Systematic Reviews - Category: International Medicine & Public Health Source Type: research
Bianca Cox1†, Maria Tsamou1†, Karen Vrijens1, Kristof Y. Neven1, Ellen Winckelmans1, Theo M. de Kok2, Michelle Plusquin1 and Tim S. Nawrot1,3* 1Center for Environmental Sciences, Hasselt University, Hasselt, Belgium 2Department of Toxicogenomics, Maastricht University, Maastricht, Netherlands 3Department of Public Health, Environment and Health Unit, Leuven University (KU Leuven), Leuven, Belgium Maternal body mass index (BMI) before pregnancy is known to affect both fetal growth and later-life health of the newborn, yet the implicated molecular mechanisms remain largely unknown. As the master reg...
Source: Frontiers in Genetics - Category: Genetics & Stem Cells Source Type: research
Publication date: Available online 11 May 2018Source: The Egyptian Journal of Radiology and Nuclear MedicineAuthor(s): Susan Adil Ali, Mohamed Gamal El-Din Mansour, Omar Farouk, Walid E. MohammedAbstractPurposeto evaluate the role of three dimentional power doppler ultrasonography (3D PDUS) of the uteroplacental circulation in early pregnancy as a screening tool for prediction of preeclampsia.Patients and methods50 pregnant women who came to do routine ultrasound scan between 11 and 13.6 weeks of pregnancy during the period from February 2016 to April 2016. Placental volume and vascularization indices were obtained, and ...
Source: The Egyptian Journal of Radiology and Nuclear Medicine - Category: Nuclear Medicine Source Type: research
CONCLUSION: Pregnant women with NAFLD have increased risk for GDM, pre-eclampsia, hypertension, hyperuricemia, increasing total cholesterol and triglycerides and should be carefully monitored during antenatal care.b. PMID: 29943682 [PubMed - as supplied by publisher]
Source: British Journal of Biomedical Science - Category: Laboratory Medicine Tags: Br J Biomed Sci Source Type: research
Management of pregnancies after combined screening for pre-eclampsia at 19-24 weeks' gestation. Ultrasound Obstet Gynecol. 2018 Jun 25;: Authors: Litwinska M, Syngelaki A, Wright A, Wright D, Nicolaides KH Abstract OBJECTIVE: To estimate the patient-specific risk of pre-eclampsia (PE) at 19-24 weeks' gestation by maternal factors and combinations of mean arterial pressure (MAP), uterine artery pulsatility index (UtA-PI), serum placental growth factor (PlGF) and serum soluble fms-like tyrosine kinase-1 (sFlt-1). On the basis of the risk of PE, the women would be stratified into high-, int...
Source: The Ultrasound Review of Obstetrics and Gynecology - Category: Radiology Authors: Tags: Ultrasound Obstet Gynecol Source Type: research
ConclusionUsing 3D ultrasound, we failed to demonstrate a difference in maternal renal perfusion in normal pregnancy compared to pre-eclampsia. The lack of observed difference may be a reflection of the high variability in 3D measurements (i.e. poor investigative tool) rather than a true lack of difference in renal perfusion.
Source: Irish Journal of Medical Science - Category: General Medicine Source Type: research
CONCLUSION: Screening by maternal factors and biomarkers at 35-37 weeks' gestation can identify a high proportion of pregnancies that develop late PE. The performance of screening depends on the racial origin of the women. This article is protected by copyright. All rights reserved. PMID: 29896778 [PubMed - as supplied by publisher]
Source: The Ultrasound Review of Obstetrics and Gynecology - Category: Radiology Authors: Tags: Ultrasound Obstet Gynecol Source Type: research
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