Lack of CFTR alters the ferret pancreatic ductal epithelial secretome and cellular proteome: Implications for exocrine/endocrine signaling

Cystic Fibrosis (CF) is caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene, which encodes a Cl – and HCO3– channel [1]. While lung disease is the most life-threatening component of CF, damage to the pancreas causes significant morbidity and worsens the progression of lung disease. In this context, acinar cell loss in the CF pancreas leads to pancreatic insufficiency and poor nutritional s tatus [2], and islet dysfunction leads to the development of CF related diabetes (CFRD) [3]—both worsen CF pulmonary function and life expectancy.

Source: Journal of Cystic Fibrosis - May 17, 2021 Category: Respiratory Medicine Authors: Pavana G. Rotti, Idil A Evans, Yulong Zhang, Bo Liang, Nathan Cunicelli, Yunxia O'Malley, Andrew W. Norris, Aliye Uc, John F. Engelhardt Tags: Original Article Source Type: research